2435-2439
| Synthesis and Biology of a 7-Nitro-2,1,3-benzoxadiazol-4-yl Derivative of 2-Phenylindole-3-acetamide: A Fluorescent Probe for the Peripheral-Type Benzodiazepine Receptor
Alan P. Kozikowski,
Maria Kotoula,
Dawei Ma,
Noureddine Boujrad,
Werner Tückmantel, and
Vassilios Papadopoulos
[Full Article -
PDF] |
2440-2444
| An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease: Computational Analysis and X-ray Crystal Structure of the Enzyme Complex
Amos B. Smith, III,
Ralph Hirschmann,
Alexander Pasternak,
Wenquing Yao, and
Paul A. Sprengeler
, M. Katharine Holloway,
Lawrence C. Kuo,
Zhongguo Chen,
Paul L. Darke, and
William A. Schleif
[Full Article -
PDF] |
2445-2451
| Identification of Highly Potent Retinoic Acid Receptor  -Selective Antagonists
Min Teng,
Tien T. Duong,
Alan T. Johnson,
Elliott S. Klein,
Liming Wang,
Berket Khalifa, and
Roshantha A. S. Chandraratna
[Full Article -
PDF] |
2452-2461
| Doxoform and Daunoform: Anthracycline-Formaldehyde Conjugates Toxic to Resistant Tumor Cells
David J. Fenick,
Dylan J. Taatjes, and
Tad H. Koch
[Full Article -
PDF] |
2462-2465
| Anti-Helicobacter pylori Agents. 1. 2-(Alkylguanidino)-4-furylthiazoles and Related Compounds
Yousuke Katsura,
Tetsuo Tomishi,
Yoshikazu Inoue,
Kazuo Sakane,
Yoshimi Matsumoto,
Hirohumi Ishikawa, and
Hisashi Takasugi
[Full Article -
PDF] |
2466-2473
| Selective Inhibitors of Monoamine Oxidase. 4. SAR of Tricyclic N-Methylcarboxamides and Congeners Binding at the Tricyclics' Hydrophilic Binding Site
Morton Harfenist,
Diane M. Joseph,
Sharon C. Spence,
Daniel P. C. Mcgee,
Mark D. Reeves, and
Helen L. White
[Full Article -
PDF] |
2474-2481
| Synthesis and Ligand Binding Studies of 4'-Iodobenzoyl Esters of Tropanes and Piperidines at the Dopamine Transporter
Satendra Singh,
Garo P. Basmadjian,
Kwasi S. Avor,
Buddy Pouw, and
Thomas W. Seale
[Full Article -
PDF] |
2482-2490
| Synthesis and in Vitro Activity of Long-Chain 5'-O-[(Alkoxycarbonyl)phosphinyl]-3'-azido-3'-deoxythymidines against Wild-Type and AZT- and Foscarnet-Resistant Strains of HIV-1
Andre Rosowsky,
Hongning Fu,
Niranjan Pai,
John Mellors,
Douglas D. Richman, and
Karl Y. Hostetler
[Full Article -
PDF] |
2491-2501
| 5-(Piperidin-2-yl)- and 5-(Homopiperidin-2-yl)-1,4-benzodiazepines: High-Affinity, Basic Ligands for the Cholecystokinin-B Receptor
José L. Castro,
Howard B. Broughton,
Michael G. N. Russell,
Denise Rathbone,
Alan P. Watt,
Richard G. Ball,
Kerry L. Chapman,
Smita Patel,
Alison J. Smith,
George R. Marshall, and
Victor G. Matassa
[Full Article -
PDF] |
2502-2524
| Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition
Michael D. Varney,
Cindy L. Palmer,
William H. Romines III,
Theodore Boritzki,
Stephen A. Margosiak,
Robert Almassy,
Cheryl A. Janson,
Charlotte Bartlett,
Eleanor J. Howland, and
Rosanne Ferre
[Full Article -
PDF] |
2525-2532
| Discovery of CGS 27023A, a Non-Peptidic, Potent, and Orally Active Stromelysin Inhibitor That Blocks Cartilage Degradation in Rabbits
Lawrence J. MacPherson*,
Erol K. Bayburt,
Michael P. Capparelli,
Brian J. Carroll,
Robert Goldstein,
Michael R. Justice,
Lijuan Zhu,
Shou-ih Hu,
Richard A. Melton,
Lynn Fryer,
Ron L. Goldberg,
John R. Doughty,
Salvatore Spirito,
Vincent Blancuzzi,
Doug Wilson,
Elizabeth M. O'Byrne,
Vishwas Ganu, and
David T. Parker*
[Full Article -
PDF] |
2533-2538
| Synthesis of Nonhydrolyzable Analogues of Thiazole-4-carboxamide and Benzamide Adenine Dinucleotide Containing Fluorine Atom at the C2' of Adenine Nucleoside: Induction of K562 Differentiation and Inosine Monophosphate Dehydrogenase Inhibitory Activity
Krystyna Lesiak,
Kyoichi A. Watanabe,
Alokes Majumdar,
Michael Seidman,
Kristen Vanderveen,
Barry M. Goldstein, and
Krzysztof W. Pankiewicz
[Full Article -
PDF] |
2539-2546
| Novel 99mTc Aminobisthiolato/Monothiolato "3 + 1" Mixed Ligand Complexes: Structure-Activity Relationships and Preliminary in Vivo Validation as Brain Blood Flow Imaging Agents
Ioannis C. Pirmettis,
Minas S. Papadopoulos, and
Efstratios Chiotellis
[Full Article -
PDF] |
2547-2554
| Steroidal Glycoside Cholesterol Absorption Inhibitors
Michael P. DeNinno,
Peter A. McCarthy,
Kimberly C. Duplantier,
Cynthia Eller,
John B. Etienne,
Michael P. Zawistoski,
Faan Wen Bangerter,
Charles E. Chandler,
Lee A. Morehouse,
Eliot D. Sugarman,
Robert W. Wilkins,
Heidi A. Woody, and
Lawrence M. Zaccaro
[Full Article -
PDF] |
2555-2562
| The Role of Phenylalanine at Position 6 in Glucagon's Mechanism of Biological Action: Multiple Replacement Analogues of Glucagon
Bassem Y. Azizeh,
Jung-Mo Ahn,
Rael Caspari,
Mark D. Shenderovich,
Dev Trivedi, and
Victor J. Hruby
[Full Article -
PDF] |
2563-2570
| The Chemistry of Pseudomonic Acid. 18. Heterocyclic Replacement of the , -Unsaturated Ester: Synthesis, Molecular Modeling, and Antibacterial Activity
Pamela Brown,
Desmond J. Best,
Nigel J. P. Broom,
Robert Cassels,
Peter J. O'Hanlon,
Timothy J. Mitchell,
Neal F. Osborne, and
Jennifer M. Wilson
[Full Article - PDF] |
2571-2578
| H3-Receptor Antagonists: Synthesis and Structure-Activity Relationships of Para- and Meta-Substituted 4(5)-Phenyl-2-[[2-[4(5)-imidazolyl]ethyl]thio]imidazoles
Marco Mor,
Fabrizio Bordi,
Claudia Silva,
Silvia Rivara,
Patrizia Crivori,
Pier Vincenzo Plazzi,
Vigilio Ballabeni,
Antonio Caretta,
Elisabetta Barocelli,
Mariannina Impicciatore,
Pierre-Alain Carrupt, and
Bernard Testa
[Full Article - PDF] |
2579-2587
| Helix-Inducing -Aminoisobutyric Acid in Opioid Mimetic Deltorphin C Analogues
Sharon D. Bryant,
Remo Guerrini,
Severo Salvadori,
Clementina Bianchi,
Roberto Tomatis,
Martti Attila, and
Lawrence H. Lazarus
[Full Article - PDF] |
2588-2595
| Mutagenesis Reveals Structure-Activity Parallels between Human A2A Adenosine Receptors and Biogenic Amine G Protein-Coupled Receptors
Qiaoling Jiang,
Brian X. Lee,
Marc Glashofer,
A. Michiel van Rhee, and
Kenneth A. Jacobson
[Full Article - PDF] |
2596-2608
| Structure-Activity Relationships of 4-(Phenylethynyl)-6-phenyl-1,4- dihydropyridines as Highly Selective A3 Adenosine Receptor Antagonists
Ji-long Jiang,
A. Michiel van Rhee,
Louis Chang,
Abraham Patchornik,
Xiao-duo Ji,
Patricia Evans,
Neli Melman, and
Kenneth A. Jacobson
[Full Article - PDF] |
2609-2625
| Design and Synthesis of Novel Imidazole-Substituted Dipeptide Amides as Potent and Selective Inhibitors of Candida albicans MyristoylCoA:Protein N-Myristoyltransferase and Identification of Related Tripeptide Inhibitors with Mechanism-Based Antifungal Activity
Balekudru Devadas,
Sandra K. Freeman,
Mark E. Zupec,
Hwang-Fun Lu,
Srinivasan R. Nagarajan,
Nandini S. Kishore,
Jennifer K. Lodge,
David W. Kuneman,
Charles A. McWherter,
Dutt V. Vinjamoori,
Daniel P. Getman,
Jeffrey I. Gordon, and
James A. Sikorski
[Full Article - PDF] |
2626-2633
| Synthesis and Antimetastatic Activity of L-Iduronic Acid-Type 1-N-Iminosugars
Yoshio Nishimura,
Takahiko Satoh,
Hayamitsu Adachi,
Shinichi Kondo,
Tomio Takeuchi,
Masayuki Azetaka,
Harumi Fukuyasu, and
Yumiko Iizuka
[Full Article - PDF] |
2634-2642
| Structure-Activity Relationships for the Antileishmanial and Antitrypanosomal Activities of 1'-Substituted 9-Anilinoacridines
Swarna A. Gamage,
David P. Figgitt,
Stanley J. Wojcik,
Raymond K. Ralph,
Adriana Ransijn,
Jacques Mauel,
Vanessa Yardley,
Diane Snowdon,
Simon L. Croft, and
William A. Denny
[Full Article - PDF] |
2643-2652
| A Novel Radioiodination Reagent for Protein Radiopharmaceuticals with L-Lysine as a Plasma-Stable Metabolizable Linkage To Liberate m-Iodohippuric Acid after Lysosomal Proteolysis
Kouji Wakisaka,
Yasushi Arano,
Takashi Uezono,
Hiromichi Akizawa,
Masahiro Ono,
Keiichi Kawai,
Yoshiro Ohomomo,
Morio Nakayama, and
Hideo Saji
[Full Article - PDF] |
2653-2656
| Synthesis and Structure-Activity Relationships of a New Model of Arylpiperazines. 3. 2-[ -(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: Study of the Influence of the Terminal Amide Fragment on 5-HT1A Affinity/Selectivity
María L. López-Rodríguez,
M. José Morcillo,
Esther Fernández,
Esther Porras,
Marta Murcia,
Antonio M. Sanz, and
Luis Orensanz
[Full Article - PDF] |
2657-2657
| Tutorials for the Biomedical Sciences. Animations, Simulations, and Calculations using Mathematica Edited by Charles Pidgeon. VCH Publishers Inc., New York. 1996. xxvii + 300 pp. 21.5 × 28 cm. ISBN 1-56081-928-6. $79.95.Advanced Tutorials for the Biomedical Sciences. Animations, Simulations, and Calculations using Mathematica Edited by Charles Pidgeon. VCH Publishers Inc., New York. 1996. xxvii + 275 pp. 21.5 × 28 cm. ISBN 1-56081-950-2. $79.95.
Donald J. Abraham
[Full Article - PDF] |
2657-2658
| Goodman & Gilman's The Pharmacological Basis of Therapeutics Edited by Joel G. Hardman, Lee E. Limbird, Perry B. Molinoff, and Raymond W. Ruddon. McGraw-Hill, New York. 1996. xxi + 1905 pp. 21 × 26 cm. ISBN 0-07-026266-7. $89.00.
S. J. Enna
[Full Article - PDF] |
2658-2658
| Textbook of Biochemistry With Clinical Correlations. Fourth Edition Edited by Thomas M. Devlin. Wiley-Liss, Inc., New York. 1997. xxvii + 1186 pp. 22.5 × 28.5 cm. ISBN 0-471-15451-2. $84.95.
Staff
[Full Article - PDF] |
2658-2659
| Dictionary of Plant Toxins Edited by Jeffrey B. Harborne and Herbert Baxter; Associate Editor Gerard P. Moss. John Wiley & Sons, Chichester. 1996. xv + 523 pp. 22 × 28.5 cm. ISBN 0-471-95107-2. $195.00.
Maurice Shamma
[Full Article - PDF] |
2659-2659
| Annual Review of Pharmacology and Toxicology. Volume 37, 1997 Edited by Arthur K. Cho. Annual Reviews, Inc., Palo Alto, CA. 1997. x + 571 pp. 16 × 23 cm. ISBN 0-8243-0437-3. $60.00.
Staff
[Full Article - PDF] |
2659-2659
| Books of Interest
[Full Article - PDF] |
2660-2660
| 2-[2'-(Dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones with Substituents at Positions 4, 8, 9, 10, and 11. Synthesis, Antitumor Activity, and Quantitative Structure-Activity Relationships
Salah M. Sami,
Robert T. Dorr,
David S. Alberts,
Anikó M. Sólyom, and
William A. Remers
[Full Article - PDF] |